STAT6 (signal transducer and activator of transcription 6)

2003-02-01 Affiliation

Identity

HGNC

STAT6

LOCATION

12q13.3

LOCUSID

6778

ALIAS

D12S1644,IL-4-STAT,STAT6B,STAT6C

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6778
MIM: 601512
HGNC: 11368
Ensembl: ENSG00000166888

Variants:

dbSNP: 6778
ClinVar: 6778
TCGA: ENSG00000166888
COSMIC: STAT6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166888	ENST00000300134	P42226
ENSG00000166888	ENST00000454075	P42226
ENSG00000166888	ENST00000537215	P42226
ENSG00000166888	ENST00000538913	P42226
ENSG00000166888	ENST00000543873	P42226
ENSG00000166888	ENST00000553275	G3V2L2
ENSG00000166888	ENST00000553397	G3V568
ENSG00000166888	ENST00000553499	G3V370
ENSG00000166888	ENST00000553533	H0YJH6
ENSG00000166888	ENST00000554663	G3V2H4
ENSG00000166888	ENST00000554764	Q5FBW6
ENSG00000166888	ENST00000555104	Q5FBW6
ENSG00000166888	ENST00000555318	H0YIY2
ENSG00000166888	ENST00000555849	G3V5K5
ENSG00000166888	ENST00000556155	P42226
ENSG00000166888	ENST00000556259	G3V5I8
ENSG00000166888	ENST00000557635	G3V2M3
ENSG00000166888	ENST00000640254	A0A1W2PNW1
ENSG00000166888	ENST00000651176	A0A494C0T4

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Jak-STAT signaling pathway	KEGG	ko04630
Jak-STAT signaling pathway	KEGG	hsa04630
Hepatitis B	KEGG	hsa05161
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
JAK-STAT signaling	KEGG	hsa_M00684
JAK-STAT signaling	KEGG	M00684
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Cytosolic sensors of pathogen-associated DNA	REACTOME	R-HSA-1834949
STING mediated induction of host immune responses	REACTOME	R-HSA-1834941
STAT6-mediated induction of chemokines	REACTOME	R-HSA-3249367
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Signal Transduction	REACTOME	R-HSA-162582
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22025054	2011	Transcriptional regulation of macrophage polarization: enabling diversity with identity.	607
20620946	2010	Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.	146
21093321	2010	STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.	142
23313952	2013	Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing.	119
27322543	2016	Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.	108
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
20624917	2010	Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.	98
18846228	2008	Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.	86
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
23313954	2013	Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.	82

Citation

Dessen P

STAT6 (signal transducer and activator of transcription 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42432/stat6