STC2 (stanniocalcin 2)

2003-08-01  

Identity

HGNC
LOCATION
5q35.2
LOCUSID
ALIAS
STC-2,STCRP
FUSION GENES

Other Information

Locus ID:

NCBI: 8614
MIM: 603665
HGNC: 11374
Ensembl: ENSG00000113739

Variants:

dbSNP: 8614
ClinVar: 8614
TCGA: ENSG00000113739
COSMIC: STC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113739ENST00000265087O76061
ENSG00000113739ENST00000265087Q6FHC9
ENSG00000113739ENST00000518455E5RG57
ENSG00000113739ENST00000520648H0YB13

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175455192007Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins.43
153673912005Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs.36
197860162010Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia.36
206192592010Stanniocalcin-2 promotes epithelial-mesenchymal transition and invasiveness in hypoxic human ovarian cancer cells.30
236648602013Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways.27
183559562008Tumor dormancy: elevated expression of stanniocalcins in late relapsing breast cancer.26
194157502009Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer.24
276626632016STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways.24
235480702013Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancer.23
179092642007Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells.21

Citation

Dessen P

STC2 (stanniocalcin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42433/stc2-(stanniocalcin-2)