STK3 (serine/threonine kinase 3)

2003-11-01  

Identity

HGNC
STK3
LOCATION
8q22.2
LOCUSID
6788
ALIAS
KRS1,MST2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6788
MIM: 605030
HGNC: 11406
Ensembl: ENSG00000104375

Variants:

dbSNP: 6788
ClinVar: 6788
TCGA: ENSG00000104375
COSMIC: STK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104375ENST00000419617Q13188
ENSG00000104375ENST00000419617A0A384MR07
ENSG00000104375ENST00000424861Q8NBU1
ENSG00000104375ENST00000518165E5RFQ9
ENSG00000104375ENST00000521649E5RIM6
ENSG00000104375ENST00000523601Q13188
ENSG00000104375ENST00000617590A0A087WZ06

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384435982024The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.1
384435982024The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.1
364957152023Mammalian STE20-like kinase-1/2 are activated in human platelets stimulated by collagen or thrombin and play a vital role in collagen-activated platelets.0
373549052023TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2.3
377394112023The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.0
378907772023Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.0
379055712023MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.3
364957152023Mammalian STE20-like kinase-1/2 are activated in human platelets stimulated by collagen or thrombin and play a vital role in collagen-activated platelets.0
373549052023TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2.3
377394112023The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation.0
378907772023Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.0
379055712023MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.3
344502492022Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.9
352534682022MST1/2 in PDGFRα(+) cells negatively regulates TGF-β-induced myofibroblast accumulation in renal fibrosis.3
354526232022High MST2 expression regulates lens epithelial cell apoptosis in age-related cataracts through YAP1 targeting GLUT1.2

Citation

Dessen P

STK3 (serine/threonine kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42439/css/lib/case-report-explorer/css/lib/dataTables.bootstrap.min.css