SUPT3H (SPT3 homolog, SAGA and STAGA complex component)

2003-05-01  

Identity

HGNC
SUPT3H
LOCATION
6p21.1
LOCUSID
8464
ALIAS
SPT3,SPT3L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8464
MIM: 602947
HGNC: 11466
Ensembl: ENSG00000196284

Variants:

dbSNP: 8464
ClinVar: 8464
TCGA: ENSG00000196284
COSMIC: SUPT3H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196284ENST00000371458Q5VWT9
ENSG00000196284ENST00000371459O75486
ENSG00000196284ENST00000371459A0A024RD67
ENSG00000196284ENST00000371460O75486
ENSG00000196284ENST00000475057O75486
ENSG00000196284ENST00000475057A0A024RD67
ENSG00000196284ENST00000637763B4E1H0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
198935842010Identification of 15 loci influencing height in a Korean population.41
179678942008STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.38
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
259344762015Genetic variants in the ADAMTS13 and SUPT3H genes are associated with ADAMTS13 activity.10
224070272012Adaptive evolution of loci covarying with the human African Pygmy phenotype.9
258602922015Identification of SUPT3H as a novel 8q24/MYC partner in blastic plasmacytoid dendritic cell neoplasm with t(6;8)(p21;q24) translocation.7
300109102018Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk.5
192591362009Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs.3

Citation

Dessen P

SUPT3H (SPT3 homolog, SAGA and STAGA complex component)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42451/supt3h-(spt3-homolog-saga-and-staga-complex-component)