SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor)

2003-11-01  

Identity

HGNC
SUPT6H
LOCATION
17q11.2
LOCUSID
6830
ALIAS
SPT6,SPT6H,emb-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6830
MIM: 601333
HGNC: 11470
Ensembl: ENSG00000109111

Variants:

dbSNP: 6830
ClinVar: 6830
TCGA: ENSG00000109111
COSMIC: SUPT6H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109111ENST00000314616Q7KZ85
ENSG00000109111ENST00000347486Q7KZ85
ENSG00000109111ENST00000577713J3QS64
ENSG00000109111ENST00000584312K7EK85

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368527002023Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6.2
374814422023Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability.3
368527002023Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6.2
374814422023Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability.3
333054802021SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression.8
335422422021SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation.8
341464812021Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo.37
342331572021Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination.25
333054802021SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression.8
335422422021SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation.8
341464812021Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo.37
342331572021Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination.25
325229802020Spt6 is a maintenance factor for centromeric CENP-A.24
329487652020SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells.14
325229802020Spt6 is a maintenance factor for centromeric CENP-A.24

Citation

Dessen P

SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42454/js/lib/zoomerang.js