TAX1BP1 (Tax1 binding protein 1)

2003-12-01  

Identity

HGNC
LOCATION
7p15.2
LOCUSID
ALIAS
CALCOCO3,T6BP,TXBP151
FUSION GENES

Other Information

Locus ID:

NCBI: 8887
MIM: 605326
HGNC: 11575
Ensembl: ENSG00000106052

Variants:

dbSNP: 8887
ClinVar: 8887
TCGA: ENSG00000106052
COSMIC: TAX1BP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106052ENST00000265393Q86VP1
ENSG00000106052ENST00000396319Q86VP1
ENSG00000106052ENST00000409980B8ZZD4
ENSG00000106052ENST00000416801F8WBU9
ENSG00000106052ENST00000418691C9J7J4
ENSG00000106052ENST00000422800C9JBZ7
ENSG00000106052ENST00000433216Q86VP1
ENSG00000106052ENST00000457186H7C3L5
ENSG00000106052ENST00000488564V9GZ06
ENSG00000106052ENST00000543117Q86VP1

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203049182010TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases.60
264519152015The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.56
232098072012TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling.44
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
176359942007T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion.37
212825162011Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.31
218854372011ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.24
233082792013RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling.17
277367722017TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.11
184344482009Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.10

Citation

Dessen P

TAX1BP1 (Tax1 binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42473/tax1bp1-(tax1-binding-protein-1)