TAX1BP1 (Tax1 binding protein 1)

2003-12-01  

Identity

HGNC
TAX1BP1
LOCATION
7p15.2
LOCUSID
8887
ALIAS
CALCOCO3,T6BP,TXBP151
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8887
MIM: 605326
HGNC: 11575
Ensembl: ENSG00000106052

Variants:

dbSNP: 8887
ClinVar: 8887
TCGA: ENSG00000106052
COSMIC: TAX1BP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106052ENST00000265393Q86VP1
ENSG00000106052ENST00000396319Q86VP1
ENSG00000106052ENST00000409980B8ZZD4
ENSG00000106052ENST00000416801F8WBU9
ENSG00000106052ENST00000418691C9J7J4
ENSG00000106052ENST00000422800C9JBZ7
ENSG00000106052ENST00000433216Q86VP1
ENSG00000106052ENST00000457186H7C3L5
ENSG00000106052ENST00000488564V9GZ06
ENSG00000106052ENST00000543117Q86VP1

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368983702023TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.9
374659572023Decreased TAX1BP1 participates in systemic lupus erythematosus by regulating monocyte/macrophage function.0
368983702023TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.9
374659572023Decreased TAX1BP1 participates in systemic lupus erythematosus by regulating monocyte/macrophage function.0
342254862021Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.30
342265952021FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.15
344711332021Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.57
342254862021Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.30
342265952021FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.15
344711332021Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.57
332071812020Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.50
332071812020Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.50
304592732018Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.25
304592732018Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.25
277367722017TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.31

Citation

Dessen P

TAX1BP1 (Tax1 binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42473/teaching-explorer/css/lib/bootstrap.min.css