TBK1 (TANK binding kinase 1)

2003-06-01  

Identity

HGNC
LOCATION
12q14.2
LOCUSID
ALIAS
FTDALS4,IIAE8,NAK,T2K
FUSION GENES

Other Information

Locus ID:

NCBI: 29110
MIM: 604834
HGNC: 11584
Ensembl: ENSG00000183735

Variants:

dbSNP: 29110
ClinVar: 29110
TCGA: ENSG00000183735
COSMIC: TBK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183735ENST00000331710Q9UHD2
ENSG00000183735ENST00000538890F5H1A3
ENSG00000183735ENST00000539810F5GZI4
ENSG00000183735ENST00000540417F5H206
ENSG00000183735ENST00000650708A0A494C0R4
ENSG00000183735ENST00000650762A0A494C0X2
ENSG00000183735ENST00000650786A0A494BZY3
ENSG00000183735ENST00000650790Q9UHD2
ENSG00000183735ENST00000650997A0A494C045
ENSG00000183735ENST00000651014A0A494C167
ENSG00000183735ENST00000651262A0A494C0A8
ENSG00000183735ENST00000651878A0A494C1I2
ENSG00000183735ENST00000652389A0A494C079
ENSG00000183735ENST00000652537A0A494C1M6
ENSG00000183735ENST00000652657A0A494C148

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Hepatitis BKEGGhsa05161
Ras signaling pathwayKEGGhsa04014
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNsREACTOMER-HSA-1606322
IRF3 mediated activation of type 1 IFNREACTOMER-HSA-1606341
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619
STAT6-mediated induction of chemokinesREACTOMER-HSA-3249367
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126925492003IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.833
198471662009Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.707
257001762015Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.286
223945622012STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.261
258038352015Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.201
170182832006RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.173
270359702016Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.155
193071772009Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.134
154892272004Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.131
191532312009Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.118

Citation

Dessen P

TBK1 (TANK binding kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42480/tbk1