TERF2IP (TERF2 interacting protein)

2003-11-01  

Identity

HGNC
LOCATION
16q23.1
LOCUSID
ALIAS
DRIP5,RAP1
FUSION GENES

Other Information

Locus ID:

NCBI: 54386
MIM: 605061
HGNC: 19246
Ensembl: ENSG00000166848

Variants:

dbSNP: 54386
ClinVar: 54386
TCGA: ENSG00000166848
COSMIC: TERF2IP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166848ENST00000300086Q9NYB0
ENSG00000166848ENST00000564671H3BR63
ENSG00000166848ENST00000569234H3BMI8
ENSG00000166848ENST00000653858A0A590UJT3

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Shelterin complexKEGGhsa_M00424
Shelterin complexKEGGM00424
Cell CycleREACTOMER-HSA-1640170
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Packaging Of Telomere EndsREACTOMER-HSA-171306
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369298402023The human RAP1 and GFAPɛ proteins increase γ-secretase activity in a yeast model system.2
369298402023The human RAP1 and GFAPɛ proteins increase γ-secretase activity in a yeast model system.2
352645622022SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition.4
352645622022SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition.4
336386202021Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.38
336386202021Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.38
314010462020SHARPIN Promotes Melanoma Progression via Rap1 Signaling Pathway.26
314850192020Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways.162
319853442020Role of telomeric RAP1 in radiation sensitivity modulation and its interaction with CSC marker KLF4 in colorectal cancer.10
328580912020Role of Rap1 in DNA damage response: implications in stem cell homeostasis and cancer.7
329762062020Constitutional variants in POT1, TERF2IP, and ACD genes in patients with melanoma in the Polish population.2
314010462020SHARPIN Promotes Melanoma Progression via Rap1 Signaling Pathway.26
314850192020Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways.162
319853442020Role of telomeric RAP1 in radiation sensitivity modulation and its interaction with CSC marker KLF4 in colorectal cancer.10
328580912020Role of Rap1 in DNA damage response: implications in stem cell homeostasis and cancer.7

Citation

Dessen P

TERF2IP (TERF2 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42523/case-report-explorer/css/lib/bootstrap.min.css