TIMP3 (TIMP metallopeptidase inhibitor 3)

2003-02-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
HSMRK222,K222,K222TA2,SFD
FUSION GENES

Other Information

Locus ID:

NCBI: 7078
MIM: 188826
HGNC: 11822
Ensembl: ENSG00000100234

Variants:

dbSNP: 7078
ClinVar: 7078
TCGA: ENSG00000100234
COSMIC: TIMP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100234ENST00000266085P35625

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA30086KDRGenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
199626682009miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.305
203858192010Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.246
203858192010Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.246
126522952003A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.180
170309882006Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.118
192964682009MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.114
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
174886542007Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3.76
203461712010MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression.74
223836952012Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.65

Citation

Dessen P

TIMP3 (TIMP metallopeptidase inhibitor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42573/timp3