TLR5 (toll like receptor 5)

2003-06-01  

Identity

HGNC
TLR5
LOCATION
1q41
LOCUSID
7100
ALIAS
MELIOS,SLE1,SLEB1,TIL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7100
MIM: 603031
HGNC: 11851
Ensembl: ENSG00000187554

Variants:

dbSNP: 7100
ClinVar: 7100
TCGA: ENSG00000187554
COSMIC: TLR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187554ENST00000407096B1AZ06
ENSG00000187554ENST00000540964O60602
ENSG00000187554ENST00000642603A0A2R8Y7Z4
ENSG00000187554ENST00000645434A0A2R8Y4Q2

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Pathogenic Escherichia coli infectionKEGGko05130
Toll-like receptor signaling pathwayKEGGhsa04620
Pathogenic Escherichia coli infectionKEGGhsa05130
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR5)REACTOMER-HSA-5603037
MyD88 deficiency (TLR5)REACTOMER-HSA-5602680
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalVariantAnnotationassociatedPD28139755
PA166048654ustekinumabChemicalClinicalAnnotationassociatedPD28696418
PA443815Crohn DiseaseDiseaseVariantAnnotationassociatedPD28139755
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD28696418

References

Pubmed IDYearTitleCitations
384820102024TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model.0
384820102024TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model.0
366081512023Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5.19
366453072023Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation.2
371189332023Upregulation of TLR5 indicates a favorable prognosis in prostate cancer.0
372776712023SPI1 Regulates the Progression of Ankylosing Spondylitis by Modulating TLR5 via NF-κB Signaling.2
373306372023Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population.0
374336852023Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation.1
378234152023Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis.1
366081512023Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5.19
366453072023Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation.2
371189332023Upregulation of TLR5 indicates a favorable prognosis in prostate cancer.0
372776712023SPI1 Regulates the Progression of Ankylosing Spondylitis by Modulating TLR5 via NF-κB Signaling.2
373306372023Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population.0
374336852023Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation.1

Citation

Dessen P

TLR5 (toll like receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42581/js/lib/js/lib/css/lib/bootstrap.min.css