TNFRSF10D (TNF receptor superfamily member 10d)

2003-06-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
CD264,DCR2,TRAIL-R4,TRAILR4,TRUNDD

Other Information

Locus ID:

NCBI: 8793
MIM: 603614
HGNC: 11907
Ensembl: ENSG00000173530

Variants:

dbSNP: 8793
ClinVar: 8793
TCGA: ENSG00000173530
COSMIC: TNFRSF10D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173530ENST00000312584Q9UBN6

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Cytokine-cytokine receptor interactionKEGGhsa04060
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Death Receptors and LigandsREACTOMER-HSA-6803211

References

Pubmed IDYearTitleCitations
169806092006Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163192252005Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.75
129155322003Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand.60
149997912004Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.45
155389682004Following a TRAIL: update on a ligand and its five receptors.43
175455222007Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.36
159167132005Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells.35
159213762005TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL.35
220288132011Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma.30

Citation

Dessen P

TNFRSF10D (TNF receptor superfamily member 10d)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42608/tnfrsf10d