TNFRSF12A (TNF receptor superfamily member 12A)

2003-06-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
CD266,FN14,TWEAKR
FUSION GENES

Other Information

Locus ID:

NCBI: 51330
MIM: 605914
HGNC: 18152
Ensembl: ENSG00000006327

Variants:

dbSNP: 51330
ClinVar: 51330
TCGA: ENSG00000006327
COSMIC: TNFRSF12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006327ENST00000326577Q9NP84
ENSG00000006327ENST00000341627Q9NP84
ENSG00000006327ENST00000573001I3L1J9
ENSG00000006327ENST00000574699I3L0S4
ENSG00000006327ENST00000575124I3L3P4
ENSG00000006327ENST00000575836I3L539

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170186102006Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.86
208440362010Regulation of tumor necrosis factor-like weak inducer of apoptosis receptor protein (TWEAKR) expression by Kaposi's sarcoma-associated herpesvirus microRNA prevents TWEAK-induced apoptosis and inflammatory cytokine expression.79
171244962006TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.72
156111302005The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression.68
226377032013Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis.68
126516232003The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors.59
124458282002Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.49
198286252009Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development.43
124964182003Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death.42
206106432010Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway.42

Citation

Dessen P

TNFRSF12A (TNF receptor superfamily member 12A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42611/tnfrsf12a