TNFRSF8 (TNF receptor superfamily member 8)

2003-05-01  

Identity

HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
CD30,D1S166E,Ki-1
FUSION GENES

Other Information

Locus ID:

NCBI: 943
MIM: 153243
HGNC: 11923
Ensembl: ENSG00000120949

Variants:

dbSNP: 943
ClinVar: 943
TCGA: ENSG00000120949
COSMIC: TNFRSF8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120949ENST00000263932P28908
ENSG00000120949ENST00000413146P28908
ENSG00000120949ENST00000417814P28908
ENSG00000120949ENST00000514649D6RAG8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165948903brentuximab vedotinChemicalLabelAnnotation, Literature, MultilinkAnnotationassociated24433361, 25200691

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
175570782007Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1.59
233438322013CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study.40
211863452011Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis.38
119711842002Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells.37
153563382004Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30).36
258405832015CD30 Downregulation, MMAE Resistance, and MDR1 Upregulation Are All Associated with Resistance to Brentuximab Vedotin.36
166518532006Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
191316272009The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription.26

Citation

Dessen P

TNFRSF8 (TNF receptor superfamily member 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42630/tnfrsf8