TNFSF11 (TNF superfamily member 11)

2003-06-01  

Identity

HGNC
TNFSF11
LOCATION
13q14.11
LOCUSID
8600
ALIAS
CD254,ODF,OPGL,OPTB2,RANKL,TNLG6B,TRANCE,hRANKL2,sOdf
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8600
MIM: 602642
HGNC: 11926
Ensembl: ENSG00000120659

Variants:

dbSNP: 8600
ClinVar: 8600
TCGA: ENSG00000120659
COSMIC: TNFSF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120659ENST00000239849O14788
ENSG00000120659ENST00000358545O14788
ENSG00000120659ENST00000358545Q54A98
ENSG00000120659ENST00000398795O14788
ENSG00000120659ENST00000398795Q5T9Y4
ENSG00000120659ENST00000405262O14788
ENSG00000120659ENST00000405262Q54A98
ENSG00000120659ENST00000544862O14788
ENSG00000120659ENST00000544862Q54A98

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594
TNFs bind their physiological receptorsREACTOMER-HSA-5669034
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA448432anastrozoleChemicalClinicalAnnotationassociatedPD
PA450196letrozoleChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
184457772008Multiple genetic loci for bone mineral density and fractures.214
184457772008Multiple genetic loci for bone mineral density and fractures.214
165721752006Regulation of cancer cell migration and bone metastasis by RANKL.205
213262022011Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling.195
176341402007Biology of RANK, RANKL, and osteoprotegerin.172
208819632010RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.155
153044862004Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1.114
219913822011Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway.109
155645642004Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin.99
165226812006Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro.98

Citation

Dessen P

TNFSF11 (TNF superfamily member 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42633/tnfsf11-(tnf-superfamily-member-11)