CD70 (CD70 molecule)

2003-06-01  

Identity

HGNC
CD70
LOCATION
19p13.3
LOCUSID
970
ALIAS
CD27-L,CD27L,CD27LG,LPFS3,TNFSF7,TNLG8A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 970
MIM: 602840
HGNC: 11937
Ensembl: ENSG00000125726

Variants:

dbSNP: 970
ClinVar: 970
TCGA: ENSG00000125726
COSMIC: CD70

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125726ENST00000245903P32970
ENSG00000125726ENST00000245903A0A0U5JA32
ENSG00000125726ENST00000597430M0QZW2

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

References

Pubmed IDYearTitleCitations
380649192024Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program.0
382798342024Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27 interaction in nasopharyngeal carcinoma.1
380649192024Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program.0
382798342024Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27 interaction in nasopharyngeal carcinoma.1
362602752023The correlation of CD70 in immune characteristics and drug therapy of pan-cancer.0
378240792023CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection.0
380303022023Delayed vaccine-induced CD8(+) T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication.2
362602752023The correlation of CD70 in immune characteristics and drug therapy of pan-cancer.0
378240792023CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection.0
380303022023Delayed vaccine-induced CD8(+) T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication.2
324275162022DNA Methylation of CD70 Promoter in Juvenile Systemic Lupus Erythematosus.4
352164582022Hypoxia-Inducible Factor-2 Alpha Regulates the Migration of Fibroblast-like Synoviocytes via Oxidative Stress-Induced CD70 Expression in Patients with Rheumatoid Arthritis.5
355509502022Epithelial-to-mesenchymal transition promotes immune escape by inducing CD70 in non-small cell lung cancer.10
359245582022Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells.2
364714812022The dual role of CD70 in B-cell lymphomagenesis.5

Citation

Dessen P

CD70 (CD70 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42643/teaching-explorer/meetings/js/lib/jquery-3.5.1.min.js