TNFSF9 (TNF superfamily member 9)

2003-06-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
4-1BB-L,CD137L,TNLG5A
FUSION GENES

Other Information

Locus ID:

NCBI: 8744
MIM: 606182
HGNC: 11939
Ensembl: ENSG00000125657

Variants:

dbSNP: 8744
ClinVar: 8744
TCGA: ENSG00000125657
COSMIC: TNFSF9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125657ENST00000245817P41273
ENSG00000125657ENST00000245817A0A0U5J8I0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

References

Pubmed IDYearTitleCitations
180261152007T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection.102
1199443920024-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function.47
174968952007Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.42
190294462009Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells.36
179729562008Marked improvement of severe progressive systemic sclerosis after transplantation of mesenchymal stem cells from an allogeneic haploidentical-related donor mediated by ligation of CD137L.32
200087912010CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.31
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
183958512008CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response.23
206703532010Ex vivo expansion of natural killer cells with high cytotoxicity by K562 cells modified to co-express major histocompatibility complex class I chain-related protein A, 4-1BB ligand, and interleukin-15.21

Citation

Dessen P

TNFSF9 (TNF superfamily member 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42645/tnfsf9