TOM1 (target of myb1 membrane trafficking protein)

2003-02-01 Affiliation

Identity

HGNC

TOM1

LOCATION

22q12.3

LOCUSID

10043

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10043
MIM: 604700
HGNC: 11982
Ensembl: ENSG00000100284

Variants:

dbSNP: 10043
ClinVar: 10043
TCGA: ENSG00000100284
COSMIC: TOM1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100284	ENST00000382034	Q6UW50
ENSG00000100284	ENST00000395736	H7BYN7
ENSG00000100284	ENST00000404284	F8WAW7
ENSG00000100284	ENST00000411850	O60784
ENSG00000100284	ENST00000424387	F8WB30
ENSG00000100284	ENST00000425375	O60784
ENSG00000100284	ENST00000439512	F8WE29
ENSG00000100284	ENST00000443206	B0QY02
ENSG00000100284	ENST00000447733	O60784
ENSG00000100284	ENST00000449058	O60784
ENSG00000100284	ENST00000449508	F8WBB0
ENSG00000100284	ENST00000456128	B0QY01
ENSG00000100284	ENST00000608674	V9GZ68
ENSG00000100284	ENST00000608749	V9GYF4

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23023224	2012	Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.	106
20083669	2010	miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression.	70
15047686	2004	Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.	47
14563850	2003	Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.	37
26007630	2015	Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.	30
25588840	2015	TOM1 is a PI5P effector involved in the regulation of endosomal maturation.	15
14613930	2004	Endofin recruits TOM1 to endosomes.	10
26320582	2015	Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.	8
15657082	2005	Endofin recruits clathrin to early endosomes via TOM1.	5
17671966	2008	Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1.	5

Citation

Dessen P

TOM1 (target of myb1 membrane trafficking protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42654/tom1-(target-of-myb1-membrane-trafficking-protein)