TOP2A (DNA topoisomerase II alpha)

2003-02-01  

Identity

HGNC
TOP2A
LOCATION
17q21.2
LOCUSID
7153
ALIAS
TOP2,TOP2alpha,TOPIIA,TP2A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7153
MIM: 126430
HGNC: 11989
Ensembl: ENSG00000131747

Variants:

dbSNP: 7153
ClinVar: 7153
TCGA: ENSG00000131747
COSMIC: TOP2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131747ENST00000423485P11388
ENSG00000131747ENST00000577541J3QR57
ENSG00000131747ENST00000581055J3KTB7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPD29938344
PA445113NeutropeniaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotation, VariantAnnotationambiguousPD29938344
PA449412doxorubicinChemicalVariantAnnotationnot associatedPD29938344
PA449476epirubicinChemicalClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
382059382024HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression.2
382871162024Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis.2
384037252024Activating the abscission checkpoint: Top2α senses chromatin bridges in cytokinesis: Top2α binds to DNA knots on chromatin bridges to activate the abscission checkpoint in human cells.0
384456102024TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation.0
385614792024The correlation study between TOP2A gene expression in circulating tumor cells and chemotherapeutic drug resistance of patients with breast cancer.0
388066102024Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer.0
382059382024HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression.2
382871162024Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis.2
384037252024Activating the abscission checkpoint: Top2α senses chromatin bridges in cytokinesis: Top2α binds to DNA knots on chromatin bridges to activate the abscission checkpoint in human cells.0
384456102024TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation.0
385614792024The correlation study between TOP2A gene expression in circulating tumor cells and chemotherapeutic drug resistance of patients with breast cancer.0
388066102024Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer.0
366564692023TOP2A Expression in Pheochromocytoma and Abdominal Paraganglioma: a Marker of Poor Clinical Outcome?0
371145472023Prognostic Significance of DNA Topoisomerase II Alpha (TOP2A) in Cholangiocarcinoma.0
371725282023The clinicopathological significance of TOP2A expression in malignant peritoneal mesothelioma.1

Citation

Dessen P

TOP2A (DNA topoisomerase II alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42659/case-report-explorer/gene-fusions-explorer/js/web-card-gene.js