TPO (thyroid peroxidase)

2003-02-01  

Identity

HGNC
TPO
LOCATION
2p25.3
LOCUSID
7173
ALIAS
MSA,TDH2A,TPX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7173
MIM: 606765
HGNC: 12015
Ensembl: ENSG00000115705

Variants:

dbSNP: 7173
ClinVar: 7173
TCGA: ENSG00000115705
COSMIC: TPO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115705ENST00000329066P07202
ENSG00000115705ENST00000345913P07202
ENSG00000115705ENST00000346956P07202
ENSG00000115705ENST00000382198P07202
ENSG00000115705ENST00000382201P07202
ENSG00000115705ENST00000382269E9PFM6
ENSG00000115705ENST00000422464H0Y6H4
ENSG00000115705ENST00000423320C9J511
ENSG00000115705ENST00000446278H7C1F5
ENSG00000115705ENST00000469607H7C5B6
ENSG00000115705ENST00000539820E9PFM6

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tyrosine metabolismKEGGko00350
Autoimmune thyroid diseaseKEGGko05320
Tyrosine metabolismKEGGhsa00350
Autoimmune thyroid diseaseKEGGhsa05320
Metabolic pathwaysKEGGhsa01100
Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxineKEGGhsa_M00043
Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxineKEGGM00043
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Thyroxine biosynthesisREACTOMER-HSA-209968

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
185090032008BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer.41
245861832014Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.37
178543962008Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake.34
201538062010Genetics and phenomics of hypothyroidism and goiter due to TPO mutations.30
205737212010Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
173346502007A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.26
174681862007High prevalence of thyroid peroxidase gene mutations in patients with thyroid dyshormonogenesis.25

Citation

Dessen P

TPO (thyroid peroxidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42681/tpo-(thyroid-peroxidase)