TRIM8 (tripartite motif containing 8)

2003-02-01  

Identity

HGNC
TRIM8
LOCATION
10q24.32
LOCUSID
81603
ALIAS
GERP,RNF27
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81603
MIM: 606125
HGNC: 15579
Ensembl: ENSG00000171206

Variants:

dbSNP: 81603
ClinVar: 81603
TCGA: ENSG00000171206
COSMIC: TRIM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171206ENST00000302424A0A2U3TZI0
ENSG00000171206ENST00000462202R4GN03
ENSG00000171206ENST00000642304A0A2R8YCF6
ENSG00000171206ENST00000642664A0A2R8YFP1
ENSG00000171206ENST00000643100A0A2R8YD00
ENSG00000171206ENST00000643376A0A2R8Y5K0
ENSG00000171206ENST00000643721Q9BZR9
ENSG00000171206ENST00000644914A0A2R8Y580
ENSG00000171206ENST00000645961A0A2R8Y500

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382378652024TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4α stability.0
388796002024Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α.0
382378652024TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4α stability.0
388796002024Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α.0
366909462023TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt.4
379148162023Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.2
366909462023TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt.4
379148162023Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.2
354707282022Circular RNA circ_0002594 regulates PDGF-BB-induced proliferation and migration of human airway smooth muscle cells via sponging miR-139-5p/TRIM8 in asthma.5
359685842022Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway.5
354707282022Circular RNA circ_0002594 regulates PDGF-BB-induced proliferation and migration of human airway smooth muscle cells via sponging miR-139-5p/TRIM8 in asthma.5
359685842022Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway.5
329292132021Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia.12
335082342021De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis.11
343295862021TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.42

Citation

Dessen P

TRIM8 (tripartite motif containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42704/js/css/js/web-card-gene.js