TRIP6 (thyroid hormone receptor interactor 6)

2003-02-01  

Identity

HGNC
TRIP6
LOCATION
7q22.1
LOCUSID
7205
ALIAS
OIP-1,OIP1,TRIP-6,TRIP6i2,ZRP-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7205
MIM: 602933
HGNC: 12311
Ensembl: ENSG00000087077

Variants:

dbSNP: 7205
ClinVar: 7205
TCGA: ENSG00000087077
COSMIC: TRIP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087077ENST00000200457Q15654
ENSG00000087077ENST00000417475Q15654
ENSG00000087077ENST00000429658H7BZE2
ENSG00000087077ENST00000437505Q15654
ENSG00000087077ENST00000619988Q15654

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
151483182004Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins.47
151483182004Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins.47
146882632004TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.36
190177432009TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.19
156570772005TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways.18
216897462011TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity.18
208763012010The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.16
292223442018TRIP6 inhibits Hippo signaling in response to tension at adherens junctions.15
176521642007ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions.13
240337042013The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth.13

Citation

Dessen P

TRIP6 (thyroid hormone receptor interactor 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42706/trip6