TRRAP (transformation/transcription domain associated protein)

2003-02-01  

Identity

HGNC
TRRAP
LOCATION
7q22.1
LOCUSID
8295
ALIAS
DEDDFA,DFNA75,PAF350/400,PAF400,STAF40,TR-AP,Tra1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8295
MIM: 603015
HGNC: 12347
Ensembl: ENSG00000196367

Variants:

dbSNP: 8295
ClinVar: 8295
TCGA: ENSG00000196367
COSMIC: TRRAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196367ENST00000355540Q9Y4A5
ENSG00000196367ENST00000359863Q9Y4A5
ENSG00000196367ENST00000360902A0A2R8YFJ4
ENSG00000196367ENST00000417523C9K0N1
ENSG00000196367ENST00000446306F2Z2U4
ENSG00000196367ENST00000456197H0Y4W2
ENSG00000196367ENST00000628380F2Z2U4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

References

Pubmed IDYearTitleCitations
163412052006Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks.231
214992472011Exome sequencing identifies GRIN2A as frequently mutated in melanoma.226
156472802005The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.79
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
176940782007Orchestration of chromatin-based processes: mind the TRRAP.54
126602462003c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation.47
120773352002TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins.46
200857412010An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.41
121381772002Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes.40
179678922008Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.26

Citation

Dessen P

TRRAP (transformation/transcription domain associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42710/trrap-(transformation-transcription-domain-associated-protein)