TSN (translin)

2003-02-01  

Identity

HGNC
TSN
LOCATION
2q14.3
LOCUSID
7247
ALIAS
BCLF-1,C3PO,RCHF1,REHF-1,TBRBP,TRSLN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7247
MIM: 600575
HGNC: 12379
Ensembl: ENSG00000211460

Variants:

dbSNP: 7247
ClinVar: 7247
TCGA: ENSG00000211460
COSMIC: TSN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000211460ENST00000389682Q15631
ENSG00000211460ENST00000409193E9PGT1
ENSG00000211460ENST00000455432H7C1D4
ENSG00000211460ENST00000467324A0A0J9YX41
ENSG00000211460ENST00000478165A0A0J9YX41
ENSG00000211460ENST00000490104A0A0J9YVW2
ENSG00000211460ENST00000490717A0A0J9YX41
ENSG00000211460ENST00000536142Q15631

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
Small interfering RNA (siRNA) biogenesisREACTOMER-HSA-426486

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198053242009Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.72
215522582011Structure of C3PO and mechanism of human RISC activation.63
147118182004Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation.22
150395552004Structure of human translin at 2.2 A resolution.15
254576132014Rescuing dicer defects via inhibition of an anti-dicing nuclease.14
155448042004The human protein translin specifically binds single-stranded microsatellite repeats, d(GT)n, and G-strand telomeric repeats, d(TTAGGG)n: a study of the binding parameters.8
124847702002Translin binding to DNA: recruitment through DNA ends and consequent conformational transitions.7
159190792005Co-expressed recombinant human Translin-Trax complex binds DNA.7
288274002017UPF1 helicase promotes TSN-mediated miRNA decay.7
117054012001Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide.6

Citation

Dessen P

TSN (translin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42715/tsn