IFT88 (intraflagellar transport 88)

2003-02-01 Affiliation

Identity

HGNC

IFT88

LOCATION

13q12.11

LOCUSID

8100

ALIAS

D13S1056E,DAF19,TG737,TTC10,hTg737

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8100
MIM: 600595
HGNC: 20606
Ensembl: ENSG00000032742

Variants:

dbSNP: 8100
ClinVar: 8100
TCGA: ENSG00000032742
COSMIC: IFT88

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000032742	ENST00000319980	Q13099
ENSG00000032742	ENST00000351808	Q13099
ENSG00000032742	ENST00000351808	A0A140VJL7
ENSG00000032742	ENST00000389373	F6SRW8
ENSG00000032742	ENST00000537103	F5H6C2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Intraflagellar transport	REACTOME	R-HSA-5620924
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog 'off' state	REACTOME	R-HSA-5610787

References

Pubmed ID	Year	Title	Citations
21441926	2011	The cilia protein IFT88 is required for spindle orientation in mitosis.	81
17264151	2007	The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells.	77
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
22941275	2012	Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model.	42
24346024	2013	Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.	26
22974282	2012	Tg737 signaling is required for hypoxia-enhanced invasion and migration of hepatoma cells.	7
29743590	2018	Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.	6
20300861	2010	Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis.	5
28489570	2017	Transcriptome profiling identifies a recurrent CRYL1-IFT88 chimeric transcript in hepatocellular carcinoma.	5
29866362	2018	Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.	3

Citation

Dessen P

IFT88 (intraflagellar transport 88)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42722/ift88