SUMO1 (small ubiquitin like modifier 1)

2003-02-01  

Identity

HGNC
LOCATION
2q33.1
LOCUSID
ALIAS
DAP1,GMP1,OFC10,PIC1,SENP2,SMT3,SMT3C,SMT3H3,UBL1
FUSION GENES

Other Information

Locus ID:

NCBI: 7341
MIM: 601912
HGNC: 12502
Ensembl: ENSG00000116030

Variants:

dbSNP: 7341
ClinVar: 7341
TCGA: ENSG00000116030
COSMIC: SUMO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116030ENST00000392244P63165
ENSG00000116030ENST00000392245P63165
ENSG00000116030ENST00000392245A0A024R3Z2
ENSG00000116030ENST00000392246P63165
ENSG00000116030ENST00000392246A0A024R3Z2
ENSG00000116030ENST00000409181B8ZZJ0
ENSG00000116030ENST00000409205B8ZZ67
ENSG00000116030ENST00000409368B8ZZN6
ENSG00000116030ENST00000409498B8ZZ67
ENSG00000116030ENST00000409627F8WBI1
ENSG00000116030ENST00000409712B9A032

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Nuclear pore complexKEGGhsa_M00427
Nuclear pore complexKEGGM00427
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is proteolytically processedREACTOMER-HSA-3065679
SUMO is conjugated to E1 (UBA2:SAE1)REACTOMER-HSA-3065676
SUMO is transferred from E1 to E2 (UBE2I, UBC9)REACTOMER-HSA-3065678
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Regulation of IFNG signalingREACTOMER-HSA-877312
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
SUMOylation of transcription factorsREACTOMER-HSA-3232118
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
Negative regulation of activity of TFAP2 (AP-2) family transcription factorsREACTOMER-HSA-8866904
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165248842006Specification of SUMO1- and SUMO2-interacting motifs.198
159312242005Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.191
149927292004SUMO promotes HDAC-mediated transcriptional repression.129
219008932011SUMO1-dependent modulation of SERCA2a in heart failure.118
126655922003Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.107
162042492005Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation.107
156601282005Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.103
164648642006Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein.99
201452082010SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor.94
154569022004Distinct in vivo dynamics of vertebrate SUMO paralogues.91

Citation

Dessen P

SUMO1 (small ubiquitin like modifier 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42758/sumo1