UGT1A9 (UDP glucuronosyltransferase family 1 member A9)

2003-08-01 Affiliation

Identity

HGNC

UGT1A9

LOCATION

2q37.1

LOCUSID

54600

ALIAS

HLUGP4,LUGP4,UDPGT,UDPGT

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54600
MIM: 606434
HGNC: 12541
Ensembl: ENSG00000241119

Variants:

dbSNP: 54600
ClinVar: 54600
TCGA: ENSG00000241119
COSMIC: UGT1A9

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000241119	ENST00000354728	O60656
ENSG00000241119	ENST00000354728	Q5DSZ5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164748728	mycophenolic acid	Chemical	ClinicalAnnotation, MultilinkAnnotation, Pathway	associated	PK		24220207, 25163792
PA164888966	raltegravir	Chemical	VariantAnnotation	associated	PK
PA165110775	SN-38	Chemical	ClinicalAnnotation, Pathway	associated	PK	PD	12181437, 16636344, 18221820, 24897286
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation	associated	PK	PD	16198654, 18946804, 20565459, 22210424, 22765258, 25163792
PA165958521	febuxostat	Chemical	ClinicalAnnotation	associated		PD	27798726
PA166119041	drug-induced liver injury	Disease	MultilinkAnnotation	associated			25446781
PA420	UGT1A1	Gene	VipGene	associated			11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated	PK	PD	16636344, 18221820
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK	PD	15761113, 21806385, 27900402, 28763744
PA444318	Gout	Disease	ClinicalAnnotation	associated		PD	27798726
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated		PD	22912756
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated	PK		29791011
PA445629	Seizures	Disease	ClinicalAnnotation	associated		PD	27900402
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	12181437, 23386248
PA446443	Liver Failure, Acute	Disease	ClinicalAnnotation	associated		PD
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated		PD
PA447230	HIV	Disease	VariantAnnotation	associated	PK
PA448015	acetaminophen	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway	associated		PD	11714888, 16696573, 23279026, 26049587
PA448320	allopurinol	Chemical	ClinicalAnnotation	associated		PD	27798726
PA449957	ibuprofen	Chemical	Pathway	associated			25502615
PA450085	irinotecan	Chemical	ClinicalAnnotation	associated	PK	PD	12181437, 16636344, 18221820, 23386248
PA450428	methotrexate	Chemical	ClinicalAnnotation	associated	PK		29791011
PA450566	mycophenolate mofetil	Chemical	ClinicalAnnotation	associated	PK	PD	16198654, 18946804, 20565459, 22210424, 22765258
PA450731	oxazepam	Chemical	Pathway	associated
PA450732	oxcarbazepine	Chemical	ClinicalAnnotation	associated		PD	27900402
PA450911	phenobarbital	Chemical	Pathway	associated			26049587
PA450947	phenytoin	Chemical	Pathway	associated			26049587
PA451141	propofol	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	18816295
PA451257	risperidone	Chemical	ClinicalAnnotation	associated		PD
PA451363	simvastatin	Chemical	ClinicalAnnotation	associated		PD	25493567
PA451550	sulfinpyrazone	Chemical	ClinicalAnnotation	associated	PK		22981363
PA451846	valproic acid	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	15761113, 21806385, 28763744
PA7000	sorafenib	Chemical	ClinicalAnnotation, Pathway	associated		PD	22912756, 28362716

References

Pubmed ID	Year	Title	Citations
38071562	2024	Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.	0
38071562	2024	Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.	0
36571650	2023	Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma.	0
36571650	2023	Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma.	0
35807350	2022	UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro.	3
35807350	2022	UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro.	3
31959879	2020	Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers.	4
32222391	2020	Worsening of Kidney Transplant Function During 2-Year Follow-up Is Associated With the Genetic Variants of CYP3A4, MDR1, and UGT1A9.	0
31959879	2020	Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers.	4
32222391	2020	Worsening of Kidney Transplant Function During 2-Year Follow-up Is Associated With the Genetic Variants of CYP3A4, MDR1, and UGT1A9.	0
30910587	2019	Epigenetic regulation of UDP-Glucuronosyltransferase by microRNA-200a/-183: implications for responses to sorafenib treatment in patients with hepatocellular carcinoma.	3
31470908	2019	Novel analytical methods to interpret large sequencing data from small sample sizes.	1
30910587	2019	Epigenetic regulation of UDP-Glucuronosyltransferase by microRNA-200a/-183: implications for responses to sorafenib treatment in patients with hepatocellular carcinoma.	3
31470908	2019	Novel analytical methods to interpret large sequencing data from small sample sizes.	1
28443723	2018	Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes.	15

Citation

Dessen P

UGT1A9 (UDP glucuronosyltransferase family 1 member A9)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42764/tumors-explorer/deep-insight-explorer/css/lib/dataTables.bootstrap.min.css