HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1)

2003-06-01  

Identity

HGNC
HUWE1
LOCATION
Xp11.22
LOCUSID
10075
ALIAS
ARF-BP1,HECTH9,HSPC272,Ib772,LASU1,MRXST,MULE,URE-B1,UREB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10075
MIM: 300697
HGNC: 30892
Ensembl: ENSG00000086758

Variants:

dbSNP: 10075
ClinVar: 10075
TCGA: ENSG00000086758
COSMIC: HUWE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086758ENST00000262854Q7Z6Z7
ENSG00000086758ENST00000262854A0A024R9W5
ENSG00000086758ENST00000342160Q7Z6Z7
ENSG00000086758ENST00000342160A0A024R9W5
ENSG00000086758ENST00000426907H0Y659
ENSG00000086758ENST00000446750A0A1B0GXC7
ENSG00000086758ENST00000468322A0A087X146
ENSG00000086758ENST00000612484Q7Z6Z7
ENSG00000086758ENST00000612484A0A024R9U8
ENSG00000086758ENST00000622887A0A087X1S3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372900642024A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals.0
378738812024The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.0
381847132024The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation.2
372900642024A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RARα pathway in Chinese individuals.0
378738812024The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.0
381847132024The E3 ligase HUWE1 increases the sensitivity of CRC to oxaliplatin through TOMM20 degradation.2
369614082023HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.2
374916062023A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant.3
369614082023HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.2
374916062023A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant.3
350325482022Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.10
354723322022E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR.2
358484472022The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression.7
359219022022TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.1
359376852022The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases.6

Citation

Dessen P

HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42770/teaching-explorer/gene-fusions/js/template.js