USP4 (ubiquitin specific peptidase 4)

2003-02-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
UNP,Unph
FUSION GENES

Other Information

Locus ID:

NCBI: 7375
MIM: 603486
HGNC: 12627
Ensembl: ENSG00000114316

Variants:

dbSNP: 7375
ClinVar: 7375
TCGA: ENSG00000114316
COSMIC: USP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114316ENST00000265560Q13107
ENSG00000114316ENST00000265560A0A024R2T0
ENSG00000114316ENST00000351842Q13107
ENSG00000114316ENST00000351842A0A024R2X6
ENSG00000114316ENST00000415188C9JNU9
ENSG00000114316ENST00000416417Q13107
ENSG00000114316ENST00000431357H7C189

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
227061602012USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.98
220295772012Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.52
213310782011USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation.51
247983422014microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression.38
233887192013USP4 positively regulates RIG-I-mediated antiviral response through deubiquitination and stabilization of RIG-I.35
222628442012Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation.33
201416122009The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway.32
261897752015Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer.28
254044032014The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange.26
164727662006UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself.24

Citation

Dessen P

USP4 (ubiquitin specific peptidase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42771/usp4