VCAM1 (vascular cell adhesion molecule 1)

2003-06-01  

Identity

HGNC
LOCATION
1p21.2
LOCUSID
ALIAS
CD106,INCAM-100
FUSION GENES

Other Information

Locus ID:

NCBI: 7412
MIM: 192225
HGNC: 12663
Ensembl: ENSG00000162692

Variants:

dbSNP: 7412
ClinVar: 7412
TCGA: ENSG00000162692
COSMIC: VCAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162692ENST00000294728P19320
ENSG00000162692ENST00000347652P19320
ENSG00000162692ENST00000370115E9PDD2
ENSG00000162692ENST00000370119P19320
ENSG00000162692ENST00000650339A0A3B3ISS8

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Leukocyte transendothelial migrationKEGGhsa04670
MalariaKEGGko05144
MalariaKEGGhsa05144
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Signaling by InterleukinsREACTOMER-HSA-449147
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182275152008MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1.312
220145782011Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.167
120820812002Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.159
221377942011VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.157
171167322006An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.117
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
245995482014Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance.80
127001372003VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration.67
184627482008Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells.62

Citation

Dessen P

VCAM1 (vascular cell adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42784/vcam1-(vascular-cell-adhesion-molecule-1)