VEGFA (vascular endothelial growth factor A)

2003-02-01  

Identity

HGNC
VEGFA
LOCATION
6p21.1
LOCUSID
7422
ALIAS
MVCD1,VEGF,VPF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7422
MIM: 192240
HGNC: 12680
Ensembl: ENSG00000112715

Variants:

dbSNP: 7422
ClinVar: 7422
TCGA: ENSG00000112715
COSMIC: VEGFA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112715ENST00000230480A2A2V4
ENSG00000112715ENST00000324450A0A0A0MR43
ENSG00000112715ENST00000372055J3KPA4
ENSG00000112715ENST00000372064A0A0A0MRQ4
ENSG00000112715ENST00000372067H3BLW8
ENSG00000112715ENST00000372077P15692
ENSG00000112715ENST00000413642A0A0A0MSI7
ENSG00000112715ENST00000417285A0A0A0MSH7
ENSG00000112715ENST00000425836A0A0A0MSH5
ENSG00000112715ENST00000457104P15692
ENSG00000112715ENST00000482630A0A0A0MTB2
ENSG00000112715ENST00000518689P15692
ENSG00000112715ENST00000518824P15692
ENSG00000112715ENST00000519767H0YBZ0
ENSG00000112715ENST00000520265H0YBI8
ENSG00000112715ENST00000520948P15692
ENSG00000112715ENST00000520948A0A024RD37
ENSG00000112715ENST00000523125P15692
ENSG00000112715ENST00000523873P15692
ENSG00000112715ENST00000523873A0A024RD33
ENSG00000112715ENST00000523950P15692
ENSG00000112715ENST00000523950A0A0Y0IMM4

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
VEGF signaling pathwayKEGGko04370
Focal adhesionKEGGko04510
Renal cell carcinomaKEGGko05211
Pancreatic cancerKEGGko05212
Bladder cancerKEGGko05219
Cytokine-cytokine receptor interactionKEGGhsa04060
VEGF signaling pathwayKEGGhsa04370
Focal adhesionKEGGhsa04510
Pathways in cancerKEGGhsa05200
Renal cell carcinomaKEGGhsa05211
Pancreatic cancerKEGGhsa05212
Bladder cancerKEGGhsa05219
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Regulation of gene expression by Hypoxia-inducible FactorREACTOMER-HSA-1234158
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD20125120, 24090479, 25955730
PA130232992bevacizumabChemicalClinicalAnnotation, PathwayassociatedPD20124951, 20125120, 23149126, 23953100, 25955730, 26100253, 27139155
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD20125120, 24090479, 25955730
PA134850558Macular DegenerationDiseaseClinicalAnnotationassociatedPD22840423, 23149126, 23559864, 23570466, 23842101
PA150481189taxanesChemicalClinicalAnnotationassociatedPD26194361
PA162372840sunitinibChemicalClinicalAnnotationassociatedPD22948895
PA164746012ranibizumabChemicalClinicalAnnotationassociatedPD22840423, 23149126, 23559864, 23570466, 23842101, 23953100
PA164771236pegaptanibChemicalClinicalAnnotationassociatedPD23953100
PA166114377hand-foot syndromeDiseaseClinicalAnnotationassociatedPD22736425
PA166114943regorafenibChemicalLabelAnnotationassociated
PA166118342afliberceptChemicalPathwayassociated20124951
PA28180FLT1GenePathwayassociated20124951
PA30086KDRGenePathwayassociated20124951
PA31783NRP1GenePathwayassociated20124951
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD24061601, 25111199, 25955730, 26100253, 27139155
PA443624Carcinoma, Renal CellDiseaseClinicalAnnotationassociatedPD
PA444447Carcinoma, HepatocellularDiseaseClinicalAnnotationassociatedPD22736425, 24510746
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD26002049
PA444606Erectile DysfunctionDiseaseClinicalAnnotationassociatedPD23007311
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD26194361
PA445425Prostatic NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD23860526, 25111199
PA445742Stomach NeoplasmsDiseaseClinicalAnnotationassociatedPD24090479
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD20125120, 25955730, 26100253, 27139155
PA446974Choroidal NeovascularizationDiseaseClinicalAnnotationassociatedPD23953100
PA448771capecitabineChemicalClinicalAnnotationassociatedPD20125120, 25955730
PA448803carboplatinChemicalClinicalAnnotationassociatedPD26194361
PA448871celecoxibChemicalPathwayassociated22336956
PA449014cisplatinChemicalClinicalAnnotationassociatedPD24090479
PA449165cyclophosphamideChemicalClinicalAnnotation, VariantAnnotationambiguousPD23860526, 25111199
PA449383docetaxelChemicalClinicalAnnotationassociatedPD24061601, 25111199, 26100253
PA449456enalaprilChemicalClinicalAnnotationassociatedPD26002049
PA450085irinotecanChemicalClinicalAnnotationassociatedPD20125120, 25955730
PA450198leucovorinChemicalClinicalAnnotationassociatedPD20125120, 25955730
PA451346sildenafilChemicalClinicalAnnotationassociatedPD23007311
PA7000sorafenibChemicalClinicalAnnotationassociatedPD22736425, 24510746

References

Pubmed IDYearTitleCitations
361210372024VEGF and Neuronal Survival.0
363306432024Hsa_circ_0004662 Accelerates the Progression of Osteoarthritis via the microRNA-424-5p/VEGFA Axis.3
373922422024The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic Variants and Their Serum Protein Levels with Breast Cancer in Egyptian Patients.0
375732622024HMOX1 Participates in Pre-Eclampsia by Regulating the Proliferation, Apoptosis, and Angiogenesis Modulation Potential of Mesenchymal Stem Cells via VEGF.0
375927832024mirna-383-5p Functions as an Anti-oncogene in Glioma through the Akt/mTOR Signaling Pathway by Targeting VEGFA.0
377499122024Vascular Endothelial Growth Factor A serum levels and common gene polymorphisms in generalized periodontitis affected patients.1
379219692024MiR-150-5p contributes to unexplained recurrent spontaneous abortion by targeting VEGFA and downregulating the PI3K/AKT/mTOR signaling pathway.0
379570272024Overexpression of VEGFA mediated by HIF-1 is associated with higher rate of spread through air spaces in resected lung adenocarcinomas.0
379662602024Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression.5
380524252024Association Between VEGF-460C/T Gene Polymorphism and Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Meta-Analysis.0
380704712024Estrogen, progesterone, cortisol, brain-derived neurotrophic factor, and vascular endothelial growth factor during the luteal phase of the menstrual cycle in women with premenstrual dysphoric disorder.0
380786932024Role of the VEGF in virus-associated cancers.1
381082782024Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.0
381603602024A Continuous Extension of Gene Set Enrichment Analysis Using the Likelihood Ratio Test Statistics Identifies Vascular Endothelial Growth Factor as a Candidate Pathway for Alzheimer's Disease via ITGA5.0
382339822024THBS1 promotes angiogenesis and accelerates ESCC malignant progression by the HIF-1/VEGF signaling pathway.1

Citation

Dessen P

VEGFA (vascular endothelial growth factor A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42787/gene-fusions-explorer/teaching-explorer/favicon/css/lib/dataTables.bootstrap.min.css