VIM (vimentin)

2003-05-01  

Identity

HGNC
LOCATION
10p13
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 7431
MIM: 193060
HGNC: 12692
Ensembl: ENSG00000026025

Variants:

dbSNP: 7431
ClinVar: 7431
TCGA: ENSG00000026025
COSMIC: VIM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000026025ENST00000224237P08670
ENSG00000026025ENST00000224237V9HWE1
ENSG00000026025ENST00000469543B0YJC5
ENSG00000026025ENST00000478746A0A1B0GTT5
ENSG00000026025ENST00000487938B0YJC4
ENSG00000026025ENST00000497849A0A1B0GVG8
ENSG00000026025ENST00000544301P08670
ENSG00000026025ENST00000544301V9HWE1

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500

Pathways

PathwaySourceExternal ID
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Muscle contractionREACTOMER-HSA-397014
Striated Muscle ContractionREACTOMER-HSA-390522
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
210575352011Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer.218
124832192003Vimentin is secreted by activated macrophages.151
127502942003Transactivation of vimentin by beta-catenin in human breast cancer cells.109
213461972011Vimentin organization modulates the formation of lamellipodia.93
162700342005PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility.89
224768512012MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer.86
227040622012Epithelial to mesenchymal transition (EMT) biomarkers--E-cadherin, beta-catenin, APC and Vimentin--in oral squamous cell carcinogenesis and transformation.84
186534732008A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin.81
199155242010Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome.75
175858782007Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion.73

Citation

Dessen P

VIM (vimentin)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42791/vim-(vimentin)