ZBTB17 (zinc finger and BTB domain containing 17)

2003-02-01  

Identity

HGNC
ZBTB17
LOCATION
1p36.13
LOCUSID
7709
ALIAS
MIZ-1,ZNF151,ZNF60,pHZ-67
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7709
MIM: 604084
HGNC: 12936
Ensembl: ENSG00000116809

Variants:

dbSNP: 7709
ClinVar: 7709
TCGA: ENSG00000116809
COSMIC: ZBTB17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116809ENST00000375733Q13105
ENSG00000116809ENST00000375743Q13105
ENSG00000116809ENST00000440560H7C1K8
ENSG00000116809ENST00000444358H0Y6X2
ENSG00000116809ENST00000537142Q13105

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
125451562003Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.109
195498442009BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma.60
191604852008A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.48
242963482013The role of MIZ-1 in MYC-dependent tumorigenesis.38
189234292008Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1.37
170505362006The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter.33
170821792007BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis.26
203084302010The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis.25
191647642009Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1.24
273397972016MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation.23

Citation

Dessen P

ZBTB17 (zinc finger and BTB domain containing 17)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42872/zbtb17-(zinc-finger-and-btb-domain-containing-17)