CBY1 (chibby family member 1, beta catenin antagonist)

2004-11-01 Affiliation

Identity

HGNC

CBY1

LOCATION

22q13.1

LOCUSID

25776

ALIAS

C22orf2,CBY,Chibby1,HS508I15A,PGEA1,PIGEA-14,PIGEA14,arb1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25776
MIM: 607757
HGNC: 1307
Ensembl: ENSG00000100211

Variants:

dbSNP: 25776
ClinVar: 25776
TCGA: ENSG00000100211
COSMIC: CBY1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100211	ENST00000216029	Q9Y3M2
ENSG00000100211	ENST00000216029	A0A024R1L9
ENSG00000100211	ENST00000396811	Q9Y3M2
ENSG00000100211	ENST00000396811	A0A024R1L9
ENSG00000100211	ENST00000411557	B0QY53
ENSG00000100211	ENST00000416285	B0QY54
ENSG00000100211	ENST00000619293	A0A087WUW0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Deactivation of the beta-catenin transactivating complex	REACTOME	R-HSA-3769402

References

Pubmed ID	Year	Title	Citations
12712206	2003	Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.	99
18573912	2008	Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity.	57
18818748	2008	Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.	31
19527514	2009	Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.	31
19940019	2010	Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling.	27
19019335	2009	Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.	26
17403895	2007	Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling.	24
22911743	2012	A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation.	22
15194699	2004	PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2.	20
20140262	2010	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.	15

Citation

Dessen P

CBY1 (chibby family member 1, beta catenin antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2004-11-01

Online version: http://atlasgeneticsoncology.org/gene/42946/cby1-(chibby-family-member-1-beta-catenin-antagonist)