CBY1 (chibby family member 1, beta catenin antagonist)

2004-11-01  

Identity

HGNC
CBY1
LOCATION
22q13.1
LOCUSID
25776
ALIAS
C22orf2,CBY,Chibby1,HS508I15A,PGEA1,PIGEA-14,PIGEA14,arb1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25776
MIM: 607757
HGNC: 1307
Ensembl: ENSG00000100211

Variants:

dbSNP: 25776
ClinVar: 25776
TCGA: ENSG00000100211
COSMIC: CBY1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100211ENST00000216029Q9Y3M2
ENSG00000100211ENST00000216029A0A024R1L9
ENSG00000100211ENST00000396811Q9Y3M2
ENSG00000100211ENST00000396811A0A024R1L9
ENSG00000100211ENST00000411557B0QY53
ENSG00000100211ENST00000416285B0QY54
ENSG00000100211ENST00000619293A0A087WUW0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

References

Pubmed IDYearTitleCitations
339340992021A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.6
339340992021A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.6
331311812020Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome.12
331311812020Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome.12
300630792019Chibby is a weak regulator of β-catenin activity in gastric epithelium.2
300630792019Chibby is a weak regulator of β-catenin activity in gastric epithelium.2
297644692018Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade.24
297644692018Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade.24
281070952017Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes.2
281070952017Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes.2
270820632016Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition.5
275286162016BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis.28
270820632016Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition.5
275286162016BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis.28
253891122015DNA methyltransferase 1 drives transcriptional down-modulation of β catenin antagonist Chibby1 associated with the BCR-ABL1 gene of chronic myeloid leukemia.4

Citation

Dessen P

CBY1 (chibby family member 1, beta catenin antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2004-11-01

Online version: http://atlasgeneticsoncology.org/gene/42946/css/teaching-explorer/js/template.js