VPS39 (VPS39 subunit of HOPS complex)

2004-11-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
TLP,VAM6,hVam6p
FUSION GENES

Other Information

Locus ID:

NCBI: 23339
MIM: 612188
HGNC: 20593
Ensembl: ENSG00000166887

Variants:

dbSNP: 23339
ClinVar: 23339
TCGA: ENSG00000166887
COSMIC: VPS39

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166887ENST00000318006Q96JC1
ENSG00000166887ENST00000318006A0A024R9L9
ENSG00000166887ENST00000348544Q96JC1
ENSG00000166887ENST00000564994H3BTU0

Expression (GTEx)

0
10
20
30
40
50
60
70
80

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203637362010Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence.43
231679632013The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion.32
214545592011Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus.27
129416982003TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.23
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
234184732013Effects of TRAP-1-like protein (TLP) gene on collagen synthesis induced by TGF-β/Smad signaling in human dermal fibroblasts.11
256552812015Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-β/Smad signaling in hypertrophic scar fibroblasts.5

Citation

Dessen P

VPS39 (VPS39 subunit of HOPS complex)

Atlas Genet Cytogenet Oncol Haematol. 2004-11-01

Online version: http://atlasgeneticsoncology.org/gene/42957/vps39