GOT1 (glutamic-oxaloacetic transaminase 1)

2007-06-01  

Identity

HGNC
GOT1
LOCATION
10q24.2
LOCUSID
2805
ALIAS
AST1,ASTQTL1,GIG18,cAspAT,cCAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2805
MIM: 138180
HGNC: 4432
Ensembl: ENSG00000120053

Variants:

dbSNP: 2805
ClinVar: 2805
TCGA: ENSG00000120053
COSMIC: GOT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120053ENST00000370508P17174
ENSG00000120053ENST00000370508A0A140VK69

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine and proline metabolismKEGGko00330
Tyrosine metabolismKEGGko00350
Phenylalanine metabolismKEGGko00360
Phenylalanine, tyrosine and tryptophan biosynthesisKEGGko00400
Arginine biosynthesisKEGGhsa00220
Arginine and proline metabolismKEGGhsa00330
Tyrosine metabolismKEGGhsa00350
Phenylalanine metabolismKEGGhsa00360
Phenylalanine, tyrosine and tryptophan biosynthesisKEGGhsa00400
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GluconeogenesisREACTOMER-HSA-70263
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614
Metabolism of polyaminesREACTOMER-HSA-351202
Methionine salvage pathwayREACTOMER-HSA-1237112
Sulfur amino acid metabolismREACTOMER-HSA-1614635

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
187523242008Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis.88
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
217507242011High frequency of CD4+ CXCR5+ TFH cells in patients with immune-active chronic hepatitis B.38
209727372010Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus.20
267911912016Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.20
193707842009Non-alcoholic steatohepatitis with normal aminotransferase values.18
166814332006Salivary aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase: possible markers in periodontal diseases?16
284552442017GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells.14
300353242018miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma.14
153066992004Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome.10

Citation

Dessen P

GOT1 (glutamic-oxaloacetic transaminase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/43000/got1-(glutamic-oxaloacetic-transaminase-1)