TOPBP1 (DNA topoisomerase II binding protein 1)

2005-11-01  

Identity

HGNC
LOCATION
3q22.1
LOCUSID
ALIAS
Dpb11,TOP2BP1
FUSION GENES

Other Information

Locus ID:

NCBI: 11073
MIM: 607760
HGNC: 17008
Ensembl: ENSG00000163781

Variants:

dbSNP: 11073
ClinVar: 11073
TCGA: ENSG00000163781
COSMIC: TOPBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163781ENST00000260810Q92547
ENSG00000163781ENST00000572787I3L1F2
ENSG00000163781ENST00000642236A0A2R8YD63

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165300422006TopBP1 activates the ATR-ATRIP complex.304
185196402008TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.150
168805172006Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.80
201595622010BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.77
219307902011TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.54
205668452010Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.51
214827172011MDC1 collaborates with TopBP1 in DNA replication checkpoint control.51
189234292008Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1.37
119348992002A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1.36
129418022003hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation.34

Citation

Dessen P

TOPBP1 (DNA topoisomerase II binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43070/topbp1