VRK3 (VRK serine/threonine kinase 3)

2005-11-01 Affiliation

Identity

HGNC

VRK3

LOCATION

19q13.33

LOCUSID

51231

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51231
HGNC: 18996
Ensembl: ENSG00000105053

Variants:

dbSNP: 51231
ClinVar: 51231
TCGA: ENSG00000105053
COSMIC: VRK3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105053	ENST00000316763	Q8IV63
ENSG00000105053	ENST00000316763	A0A024QZI4
ENSG00000105053	ENST00000377011	Q8IV63
ENSG00000105053	ENST00000593912	M0R3H2
ENSG00000105053	ENST00000593919	M0QYA8
ENSG00000105053	ENST00000594090	M0R164
ENSG00000105053	ENST00000594092	Q8IV63
ENSG00000105053	ENST00000594948	Q8IV63
ENSG00000105053	ENST00000594948	A0A024QZI4
ENSG00000105053	ENST00000596121	M0QYG0
ENSG00000105053	ENST00000596445	M0QXD7
ENSG00000105053	ENST00000596814	M0R200
ENSG00000105053	ENST00000597215	M0R025
ENSG00000105053	ENST00000599342	M0R164
ENSG00000105053	ENST00000599538	Q8IV63
ENSG00000105053	ENST00000599538	A0A024QZI4
ENSG00000105053	ENST00000600137	M0QX88
ENSG00000105053	ENST00000600259	M0QXV1
ENSG00000105053	ENST00000601324	M0QZ79
ENSG00000105053	ENST00000601341	Q8IV63
ENSG00000105053	ENST00000601912	M0R073

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinases	REACTOME	R-HSA-450282
ERK/MAPK targets	REACTOME	R-HSA-198753
ERKs are inactivated	REACTOME	R-HSA-202670
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Nuclear Events (kinase and transcription factor activation)	REACTOME	R-HSA-198725

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33067254	2020	RNF144a induces ERK-dependent cell death under oxidative stress via downregulation of vaccinia-related kinase 3.	3
33067254	2020	RNF144a induces ERK-dependent cell death under oxidative stress via downregulation of vaccinia-related kinase 3.	3
31324890	2019	A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival.	10
31324890	2019	A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival.	10
28412365	2017	Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells.	1
28927264	2017	Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer.	7
28412365	2017	Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells.	1
28927264	2017	Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer.	7
27346674	2016	Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation.	8
27941812	2016	VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity.	8
27346674	2016	Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation.	8
27941812	2016	VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity.	8
25899223	2015	Presumed pseudokinase VRK3 functions as a BAF kinase.	17
25899223	2015	Presumed pseudokinase VRK3 functions as a BAF kinase.	17
23082977	2013	Role of bivalent cations in structural stabilities of new drug targets--vaccinia-related kinases (VRK) from molecular dynamics simulations.	1

Citation

Dessen P

VRK3 (VRK serine/threonine kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43075/deep-insight-explorer/js/lib/img/logo-atlas-4.svg