ARHGEF10 (Rho guanine nucleotide exchange factor 10)

2006-10-01  

Identity

HGNC
ARHGEF10
LOCATION
8p23.3
LOCUSID
9639
ALIAS
GEF10,SNCV

Other Information

Locus ID:

NCBI: 9639
MIM: 608136
HGNC: 14103
Ensembl: ENSG00000104728

Variants:

dbSNP: 9639
ClinVar: 9639
TCGA: ENSG00000104728
COSMIC: ARHGEF10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104728ENST00000349830O15013
ENSG00000104728ENST00000398560E9PB39
ENSG00000104728ENST00000398564O15013
ENSG00000104728ENST00000518288O15013
ENSG00000104728ENST00000520359O15013
ENSG00000104728ENST00000522435H0YAN8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
178937072008An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia.44
145087092003Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10.39
200424622010Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke.15
200424622010Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke.15
168968042006Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture.12
261435282015Association of the Charcot-Marie-Tooth disease gene ARHGEF10 with paclitaxel induced peripheral neuropathy in NCCTG N08CA (Alliance).12
196351682009Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.10
217197012011Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).9
275505192016ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles.6

Citation

Dessen P

ARHGEF10 (Rho guanine nucleotide exchange factor 10)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43144/arhgef10