NAIP (NLR family apoptosis inhibitory protein)

2007-02-01  

Identity

HGNC
NAIP
LOCATION
5q13.2
LOCUSID
4671
ALIAS
BIRC1,NLRB1,psiNAIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4671
MIM: 600355
HGNC: 7634
Ensembl: ENSG00000249437

Variants:

dbSNP: 4671
ClinVar: 4671
TCGA: ENSG00000249437
COSMIC: NAIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000249437ENST00000194097Q13075
ENSG00000249437ENST00000503719Q13075
ENSG00000249437ENST00000508426E7EQW0
ENSG00000249437ENST00000514857H0YAX2
ENSG00000249437ENST00000517649Q13075
ENSG00000249437ENST00000519014E5RJA3
ENSG00000249437ENST00000523981Q13075

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
239403712013Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation.121
230123632012Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.62
184536012008NAIP and Ipaf control Legionella pneumophila replication in human cells.48
172220622007Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution.39
261096482015Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin.32
152803662004Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9.21
194884002009A novel protein isoform of the multicopy human NAIP gene derives from intragenic Alu SINE promoters.20
188423672009Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy.17
188423672009Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy.17
187590602009Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM).16

Citation

Dessen P

NAIP (NLR family apoptosis inhibitory protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43168/naip-(nlr-family-apoptosis-inhibitory-protein)