CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
CAMKKA
FUSION GENES

Other Information

Locus ID:

NCBI: 84254
MIM: 611411
HGNC: 1469
Ensembl: ENSG00000004660

Variants:

dbSNP: 84254
ClinVar: 84254
TCGA: ENSG00000004660
COSMIC: CAMKK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004660ENST00000158166Q8N5S9
ENSG00000004660ENST00000348335Q8N5S9
ENSG00000004660ENST00000381769J3KPJ3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Post NMDA receptor activation eventsREACTOMER-HSA-438064
CREB phosphorylation through the activation of CaMKKREACTOMER-HSA-442717

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186950472008CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology.167
195208432009Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.68
167411612006Variants in the GH-IGF axis confer susceptibility to lung cancer.41
201069002010International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.26
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
256798682015Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.6
271512162016Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.6
237372882013Polymorphism rs7214723 in CAMKK1 and lung cancer risk in Chinese population.4
182705932008Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile.2

Citation

Dessen P

CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43185/camkk1