CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1)

2006-10-01  

Identity

HGNC
CAMKK1
LOCATION
17p13.2
LOCUSID
84254
ALIAS
CAMKKA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84254
MIM: 611411
HGNC: 1469
Ensembl: ENSG00000004660

Variants:

dbSNP: 84254
ClinVar: 84254
TCGA: ENSG00000004660
COSMIC: CAMKK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004660ENST00000158166Q8N5S9
ENSG00000004660ENST00000348335Q8N5S9
ENSG00000004660ENST00000381769J3KPJ3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Post NMDA receptor activation eventsREACTOMER-HSA-438064
CREB phosphorylation through the activation of CaMKKREACTOMER-HSA-442717

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
341655052021Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases.3
341655052021Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases.3
271512162016Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.22
271512162016Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.22
256798682015Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.12
256798682015Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.12
237372882013Polymorphism rs7214723 in CAMKK1 and lung cancer risk in Chinese population.7
237372882013Polymorphism rs7214723 in CAMKK1 and lung cancer risk in Chinese population.7
201069002010International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.32
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.26
201069002010International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.32
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.26
195208432009Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.93
195208432009Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.93
182705932008Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile.5

Citation

Dessen P

CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43185/teaching-explorer/css/haematological-explorer/js/lib/popper.js