CDC5L (cell division cycle 5 like)

2006-10-01 Affiliation

Identity

HGNC

CDC5L

LOCATION

6p21.1

LOCUSID

988

ALIAS

CDC5,CDC5-LIKE,CEF1,PCDC5RP,dJ319D22.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 988
MIM: 602868
HGNC: 1743
Ensembl: ENSG00000096401

Variants:

dbSNP: 988
ClinVar: 988
TCGA: ENSG00000096401
COSMIC: CDC5L

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000096401	ENST00000371477	Q99459

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Spliceosome, Prp19/CDC5L complex	KEGG	hsa_M00353
Spliceosome, 35S U5-snRNP	KEGG	hsa_M00355
Spliceosome, Prp19/CDC5L complex	KEGG	M00353
Spliceosome, 35S U5-snRNP	KEGG	M00355
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445218	Pancreatic Neoplasms	Disease	ClinicalAnnotation	associated		PD	22838950
PA449748	gemcitabine	Chemical	ClinicalAnnotation	associated		PD	22838950

References

Pubmed ID	Year	Title	Citations
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
19633697	2009	Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.	39
18567798	2008	Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma.	31
20467437	2010	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	28
21385873	2011	CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.	17
21036905	2010	Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.	16
24675469	2014	Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe.	14
18330920	2008	Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine.	12
18583928	2008	Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.	10
29871935	2018	Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit.	10

Citation

Dessen P

CDC5L (cell division cycle 5 like)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43199/cdc5l-(cell-division-cycle-5-like)