NUF2 (NUF2 component of NDC80 kinetochore complex)

2006-10-01  

Identity

HGNC
NUF2
LOCATION
1q23.3
LOCUSID
83540
ALIAS
CDCA1,CT106,NUF2R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83540
MIM: 611772
HGNC: 14621
Ensembl: ENSG00000143228

Variants:

dbSNP: 83540
ClinVar: 83540
TCGA: ENSG00000143228
COSMIC: NUF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143228ENST00000271452Q9BZD4
ENSG00000143228ENST00000367900Q9BZD4
ENSG00000143228ENST00000442820B1AQT4
ENSG00000143228ENST00000450453B1AQT3
ENSG00000143228ENST00000497990E9PP32
ENSG00000143228ENST00000524800E9PQC4
ENSG00000143228ENST00000534289E9PKH1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

References

Pubmed IDYearTitleCitations
366704232023NUF2 promotes tumorigenesis by interacting with HNRNPA2B1 via PI3K/AKT/mTOR pathway in ovarian cancer.2
368356372023NUF2 Promotes Breast Cancer Development as a New Tumor Stem Cell Indicator.4
370569302023NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1.4
371382622023NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma.0
374882942023FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner.0
366704232023NUF2 promotes tumorigenesis by interacting with HNRNPA2B1 via PI3K/AKT/mTOR pathway in ovarian cancer.2
368356372023NUF2 Promotes Breast Cancer Development as a New Tumor Stem Cell Indicator.4
370569302023NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1.4
371382622023NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma.0
374882942023FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner.0
356000432022NUF2 Is a Potential Immunological and Prognostic Marker for Non-Small-Cell Lung Cancer.3
357959882022ANP32E contributes to gastric cancer progression via NUF2 upregulation.2
358134772022NUF2 Drives Clear Cell Renal Cell Carcinoma by Activating HMGA2 Transcription through KDM2A-mediated H3K36me2 Demethylation.7
356000432022NUF2 Is a Potential Immunological and Prognostic Marker for Non-Small-Cell Lung Cancer.3
357959882022ANP32E contributes to gastric cancer progression via NUF2 upregulation.2

Citation

Dessen P

NUF2 (NUF2 component of NDC80 kinetochore complex)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43200/favicon/js/web-card-_common.js