CDK9 (cyclin dependent kinase 9)

2006-10-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
C-2k,CDC2L4,CTK1,PITALRE,TAK
FUSION GENES

Other Information

Locus ID:

NCBI: 1025
MIM: 603251
HGNC: 1780
Ensembl: ENSG00000136807

Variants:

dbSNP: 1025
ClinVar: 1025
TCGA: ENSG00000136807
COSMIC: CDK9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136807ENST00000373264P50750
ENSG00000136807ENST00000373264A0A024R880
ENSG00000136807ENST00000421939X6RE90

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription ElongationREACTOMER-HSA-167169
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Tat-mediated HIV elongation arrest and recoveryREACTOMER-HSA-167243
Pausing and recovery of Tat-mediated HIV elongationREACTOMER-HSA-167238
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Tat with host cellular proteinsREACTOMER-HSA-176034
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180398612008Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression.143
228954302012The super elongation complex (SEC) family in transcriptional control.139
185665852008The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.121
128324722003MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.119
184832222008PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.106
159652332005Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.103
146277022004Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.87
286735422017BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.76
195750112009CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.72
169806112006Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation.63

Citation

Dessen P

CDK9 (cyclin dependent kinase 9)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43202/cdk9-(cyclin-dependent-kinase-9)