CHD1 (chromodomain helicase DNA binding protein 1)

2006-10-01  

Identity

HGNC
LOCATION
5q15
LOCUSID
ALIAS
CHD-1,PILBOS
FUSION GENES

Other Information

Locus ID:

NCBI: 1105
MIM: 602118
HGNC: 1915
Ensembl: ENSG00000153922

Variants:

dbSNP: 1105
ClinVar: 1105
TCGA: ENSG00000153922
COSMIC: CHD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153922ENST00000284049O14646
ENSG00000153922ENST00000505657H0Y8V4
ENSG00000153922ENST00000511067A0A087WVF4
ENSG00000153922ENST00000512844H0Y8Z0
ENSG00000153922ENST00000614616O14646

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163720142005Double chromodomains cooperate to recognize the methylated histone H3 tail.215
162637262005Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.155
196254492009CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
219793732011Mediator coordinates PIC assembly with recruitment of CHD1.55
281665372017Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.49
221798242012Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness.44
221390822012Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer.42
247356152014Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2.41
257702902015Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer.33

Citation

Dessen P

CHD1 (chromodomain helicase DNA binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43208/chd1