CLK1 (CDC like kinase 1)

2006-10-01  

Identity

HGNC
CLK1
LOCATION
2q33.1
LOCUSID
1195
ALIAS
CLK,CLK/STY,STY
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1195
MIM: 601951
HGNC: 2068
Ensembl: ENSG00000013441

Variants:

dbSNP: 1195
ClinVar: 1195
TCGA: ENSG00000013441
COSMIC: CLK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000013441ENST00000321356P49759
ENSG00000013441ENST00000409403F8WBF5
ENSG00000013441ENST00000409769B8ZZR0
ENSG00000013441ENST00000432425P49759
ENSG00000013441ENST00000434813P49759
ENSG00000013441ENST00000621181A0A087WVK0

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376073292023Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders.2
376073292023Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders.2
323591912021A conserved sequence motif bridges two protein kinases for enhanced phosphorylation and nuclear function of a splicing factor.6
338111402021CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly.7
323591912021A conserved sequence motif bridges two protein kinases for enhanced phosphorylation and nuclear function of a splicing factor.6
338111402021CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly.7
317825502020LncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation.60
323332322020Phosphoproteomic analysis identifies CLK1 as a novel therapeutic target in gastric cancer.20
317825502020LncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation.60
323332322020Phosphoproteomic analysis identifies CLK1 as a novel therapeutic target in gastric cancer.20
310648402019Disordered protein interactions for an ordered cellular transition: Cdc2-like kinase 1 is transported to the nucleus via its Ser-Arg protein substrate.5
310648402019Disordered protein interactions for an ordered cellular transition: Cdc2-like kinase 1 is transported to the nucleus via its Ser-Arg protein substrate.5
293353012018Mobilization of a splicing factor through a nuclear kinase-kinase complex.18
298029952018Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention.18
293353012018Mobilization of a splicing factor through a nuclear kinase-kinase complex.18

Citation

Dessen P

CLK1 (CDC like kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43215/favicon/css/lib/bootstrap.min.css