EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4)

2006-10-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
GCN2,PVOD2
FUSION GENES

Other Information

Locus ID:

NCBI: 440275
MIM: 609280
HGNC: 19687
Ensembl: ENSG00000128829

Variants:

dbSNP: 440275
ClinVar: 440275
TCGA: ENSG00000128829
COSMIC: EIF2AK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128829ENST00000263791Q9P2K8
ENSG00000128829ENST00000558823H0YNY9
ENSG00000128829ENST00000559624Q9P2K8
ENSG00000128829ENST00000560648H0YND8
ENSG00000128829ENST00000560855H0YME5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD24751813
PA449841haloperidolChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD24751813, 27023437
PA450688olanzapineChemicalClinicalAnnotationassociatedPD24751813
PA451201quetiapineChemicalClinicalAnnotationassociatedPD24751813
PA451257risperidoneChemicalClinicalAnnotationassociatedPD24751813
PA451974ziprasidoneChemicalClinicalAnnotationassociatedPD24751813

References

Pubmed IDYearTitleCitations
381757552024Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes.2
382811372024Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions.1
381757552024Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes.2
382811372024Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions.1
364761912023Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis.4
366333832023A new mutation in the EIF2AK4 gene in familial pulmonary veno-occlusive disease.1
369017142023Multiple Roles of the Stress Sensor GCN2 in Immune Cells.5
370175292023Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.1
371996442023Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival.0
364761912023Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis.4
366333832023A new mutation in the EIF2AK4 gene in familial pulmonary veno-occlusive disease.1
369017142023Multiple Roles of the Stress Sensor GCN2 in Immune Cells.5
370175292023Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.1
371996442023Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival.0
351374492022Amino acid restriction induces a long non-coding RNA UBA6-AS1 to regulate GCN2-mediated integrated stress response in breast cancer.6

Citation

Dessen P

EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43241/haematological-explorer/css/img/logo-atlas-4.svg