ERN2 (endoplasmic reticulum to nucleus signaling 2)

2006-10-01  

Identity

HGNC
ERN2
LOCATION
16p12.2
LOCUSID
10595
ALIAS
IRE1-BETA,IRE1b,IRE2p,hIRE2p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10595
MIM: 604034
HGNC: 16942
Ensembl: ENSG00000134398

Variants:

dbSNP: 10595
ClinVar: 10595
TCGA: ENSG00000134398
COSMIC: ERN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134398ENST00000256797Q76MJ5
ENSG00000134398ENST00000457008E7ETG2
ENSG00000134398ENST00000562458H3BSU1
ENSG00000134398ENST00000562562H3BTW8
ENSG00000134398ENST00000569903H3BUU2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
319857472020IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress.25
328812992020EEF1A2 and ERN2 could potentially discriminate metastatic status of mediastinal lymph node in lung adenocarcinomas harboring EGFR 19Del/L858R mutations.2
319857472020IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress.25
328812992020EEF1A2 and ERN2 could potentially discriminate metastatic status of mediastinal lymph node in lung adenocarcinomas harboring EGFR 19Del/L858R mutations.2
309737542019XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.44
309737542019XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.44
277746542017Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1α and β-dependent decay and miRNA.10
277746542017Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1α and β-dependent decay and miRNA.10
232364642012Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β.27
232364642012Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β.27
211465302011Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins.24
211465302011Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins.24
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

ERN2 (endoplasmic reticulum to nucleus signaling 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43248/haematological-explorer/gene-fusions-explorer/gene-fusions/img/logo-atlas-4.svg